We study proteins and molecular mechanisms of protein misfolding and
aggregation in Alzheimer's Disease and in protein folding diseases
The laboratory is a vibrant workplace composed by passionate and curious team members from different backgrounds, nationalities and training levels.
28/06/2024
Congratulations to the team for a great participation and awards (best presentation, best pitch presentation, poster honorable mention) at the 4th Chem & Biochem Students Meeting Departamento de Química e Bioquímica, Ciências ULisboa Faculdade de Ciências da Universidade de Lisboa. Thank you and congrats to the organizers of for superbly organized meeting!
28/06/2024
Grateful for having received an honorable mention 🎖 in Biomedical Sciences in the 2024 ULisboa/CGD Scientific Awards! I dedicate this recognition to my amazing research team 👩🔬👨🔬 at Ciências/BioISI and collaborators for their contributions to our studies on protein misfolding and aggregation in Alzheimer's neurodegeneration 🧠 and protein folding diseases
22/06/2024
👩🔬 Bárbara Henriques, docente de CIÊNCIAS e investigadora no BioISI - Biosystems & Integrative Sciences Institute, fala ao 90 Segundos de Ciência sobre a sua investigação. Esta foca-se na criação de uma base de dados que uniformiza a informação clínica sobre a deficiência múltipla das desidrogenases dos ácidos gordos, uma doença metabólica rara que faz parte do rastreio do teste do pezinho. 🦶
🎙 Ouve o episódio aqui 👉 t.ly/oc5MY
26/02/2024
👏Very well done by our MSc Andreia Dias👩🔬,BioISI junior fellow, during the 6th edition of the student meeting of the Mestrado em Bioquímica e Biomedicina at Faculdade de Ciências da Universidade de Lisboa, presenting work on protein folding defects in neurological🧠 supervised by
Bárbara Joana Henriques
25/02/2024
Happy to have contributed our expertise on Abeta42 aggregation kinetics to this collaborative study with impact on 🧠 with 🇵🇹🇳🇱 BioISI - Biosystems & Integrative Sciences Institute BioISI
https://www.nature.com/articles/s42003-024-05806-5
BioISI Ciências Universidade de Lisboa
M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue - Communications Biology Bacteriophages displaying amyloidogenic peptides are able to identify amyloid-beta oligomers in post-mortem brain tissue of APP/PS1-transgenic mice and of Alzheimer patients.
19/12/2023
📣Congratulations to our Marta Botelho, just graduated 🎓from
Ciências Universidade Lisboa MSc Bioquímica e Biomedicina with great research on effect of S100 chaperones on aggregation🧠Thanks Wa**er MDC 🇩🇪 and Herrera FCUL 🇵🇹 labs for collaboration! 👏 BioISI
28/11/2023
O nosso projeto 🇪🇺 TWINPIPSA em entrevista no Antena 2 Ciência
🔈Podcast: www.rtp.pt/play/p783/e730683/antena2-ciencia ➡️ Projeto para estudar a fundo as proteínas. Projeto internacional, que reúne investigadores das Universidade de Lisboa, Copenhaga, Cambridge e Tel Aviv, para estudar a fundo as proteínas com impactos e aplicações em biomedicina e biotecnologia.
Faculdade de Ciências da Universidade de Lisboa
BioISI - Biosystems & Integrative Sciences Institute
Antena 2 Ciência Episódio 39 - de 27 nov 2023 - RTP Play - RTP Antena 2 Ciência - Projeto internacional, que reúne investigadores das Universidades de Lisboa, Copenhaga, Cambridge e Tel Aviv, para estudar a fund
28/11/2023
Congratulations to Mariana Santos which just graduated with flying colours 👏 Mestrado em Bioquímica e Biomedicina Faculdade de Ciências da Universidade de Lisboa BioISI - Biosystems & Integrative Sciences Institute
14/07/2023
Very proud of lab members 👩🔬👨🔬for their active participation and 🎖️awards won at the 3rd Chem&Biochem meeting yesterday at Departamento de Química e Bioquímica, Ciências ULisboa
Faculdade de Ciências da Universidade de Lisboa - great opportunity to share our latest research!
01/06/2023
I am thrilled to share the news of my promotion to Full Professor at Faculdade de Ciências! I want to express my deepest gratitude to my students, collaborators, colleagues, mentors, and institutions for their unwavering support throughout my career. Special thanks to my incredible family for their constant encouragement. Exciting times ahead at Universidade de Lisboa - Thank you all!
29/03/2023
📣Our latest paper out in Frontiers in investigates how S100B chaperone multimers act as complementary suppressors of Aβ42 oligomers and aggregation, underpinning a potential neuroprotective role in Disease🧠 Work spearheaded by 2y PhD student António Figueira and collaboration BioISI Faculdade Ciências Universidade Lisboa ICBAS Instituto de Investigação e Inovação em Saúde Universidade do Porto
S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation Extracellular aggregation of the amyloid-β 1–42 (Aβ42) peptide is a major hallmark of Alzheimer’s disease (AD), with recent data suggesting that Aβ intermediate oligomers (AβO) are more cytotoxic than mature amyloid fibrils. Understanding how chaperones harness such amyloid oligomers is crit...
13/03/2023
Congratulations Beatriz and all the best for the rest!
Mestrado em Bioquímica e Biomedicina FCUL
BioISI - Biosystems & Integrative Sciences Institute