JACC Journals

A 71-year-old woman with a failing Perceval valve with high-risk coronary anatomy precluding chimney stenting and Bioprosthetic Aortic Scallop Intentional Laceration to prevent Iatrogenic Coronary Artery obstruction. Leaflet traversal of the right coronary cusp was achieved through an MPA1 guide. The guide was advanced across the bioprosthetic frame into the left ventricle immediately post-traversal to secure position. This facilitated wire exchange and leaflet laceration. A balloon-expandable valve was then successfully implanted.

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In a study of approximately 90,000 UK Biobank participants wearing a wrist-worn activity tracker for 1 week, greater sedentary time was associated with a higher risk of 75 conditions, especially CKM conditions, independent of MVPA levels. Avoiding excess sedentary behavior should be a key public health target.

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A 78-year-old man with permanent atrial fibrillation and recurrent obscure gastrointestinal bleeding was evaluated for potential left atrial appendage (LAA) occlusion. Transesophageal echocardiography and cardiac magnetic resonance imaging demonstrated congenital absence of the LAA without evidence of atrial thrombus. Considering the patient's high bleeding risk, anticoagulation therapy was discontinued after multidisciplinary assessment.

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Congenital Absence of the Left Atrial Appendage in Atrial Fibrillation With Gastrointestinal Bleeding: AbstractBackgroundAtrial fibrillation (AF) increases the risk of thromboembolic events, most commonly owing to thrombus formation in the left atrial appendage (LAA). Anticoagulation reduces thrombo...

🫀 SGLT2 inhibitors may have potential beyond diabetes—offering anti-inflammatory, antifibrotic, and endothelial benefits that could slow valvular damage in rheumatic heart disease. Early hypothesis, but clinical trials are needed to define their true disease-modifying role.

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Policy works when it's targeted right. The Inflation Reduction Act’s low-income expansion dropped cost-related cardiovascular drug nonadherence by 5.5%, throwing a vital financial lifeline to ~70,000 vulnerable seniors.

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Mitral annular disjunction is common in pediatric Loeys-Dietz Syndrome. Disjunction was associated with mitral valve prolapse, increased risk of aortic events, and arrhythmias.

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ASD, VSD, PDA, AVSD: when is routine surveillance enough and when is intervention the better path?

The 2026 ACC Concise Clinical Guidance translates available evidence into practical outpatient follow-up algorithms for pediatric cardiology practice.

🔗 https://bit.ly/43zcoxd

The Single Ventricle Reconstruction trial found no overall long-term outcome difference by Norwood shunt type. Does that make shunt choice irrelevant? Not quite. The bigger challenge is reducing lifelong morbidity in single-ventricle care. https://bit.ly/4fDqEwc

The 2026 AHA/ACC/ADA/ASN Cardiovascular-Kidney-Metabolic (CKM) Syndrome Guideline-at-a-Glance highlights CKM syndrome staging, PREVENT cardiovascular (CV) risk assessment, obesity and metabolic management strategies, kidney-protective therapies, and interdisciplinary approaches for reducing long-term CV and kidney risk.

Get started with implementing key recommendations into everyday clinical practice: https://bit.ly/4emLZrA